Here's a brief summary of what happened during our most recent session: the girls returned to the city, resolved some dangling threads, asked many questions of many NPCs, were offered dozens of plot-hooks and juicy possible goals, and decided to leave the city in the direction of none of them.*
There was a great debate between the girls about which way to go, but in the end, simple wanderlust won out.
They had NPCs saying "Arrrr, to the This Direction there be This Thing!" and "Oh, if it be ____ ye seek, then to ____ ye should go!" and "If nothing is done about____ then a horrific _____ may indeed befall us all!" and they basically went, Ok, well we know what's going to happen in all those cases, so let's do something else entirely.
Despite the fact that it means I've just written a bunch of D&D material to go in all those directions that may never get used, I'm very happy, since it displays a touching faith in the creative powers of their DM. Oh, of course there's something over in this empty corner of the map between Vornheim and Osc Lithicum.
So now I have to figure out what's there. Using absolutely none of the ideas I've already dangled.
Anybody wanna buy some plot hooks?
And no, I will not just re-skin all those ideas and move them around the map. Then what'd be the point of the party choosing not to do them?
*This was one of our filmed sessions, so if you truly crave more detail, you'll be able to see it in about a month.