...it may be what in the old days was called a spiritual crisis or whatever. It’s just the feeling as though the entire, every axiom of your life turned out to be false, and there was actually nothing, and you were nothing, and it was all a delusion. And that you were better than everyone else because you saw that it was a delusion, and yet you were worse because you couldn’t function.
What's interesting for RPG fans here is: that is exactly how the Cthulhu Mythos stat in Call of Cthulhu works. The more useful things you know about the Cthulhu stuff--the real engine of the universe--the lower your max Sanity.